A Peculiar Case of Darier's Disease in a Patient with HIV Infection

Abstract

Darier's disease also known as Darier-White disease or Keratosis follicularis is a rare
genodermatosis with autosomal dominant inheritance first described in 1886 by Marrow and
later in 1889 by Darier and White. It has a high penetrance and variable expression although many
cases also occur sporadically. The disease occurs due to a mutation in the gene ATP2A2 which
encodes the sarcoplasmic/endoplasmic reticulum 2+ Ca ATPase type 2 protein (SERCA2) at
1,3 chromosome 12q23–24.1.

We report a case of Darier's disease in a treatment naïve newly diagnosed HIV positive patient whose
lesions improved markedly after commencement of Anti-Retroviral Therapy (ART).